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Matilda Benyesh-Melnick, MD, was born on February 7, 1926 in Russe, Bulgaria. She earned her medical degree from Hebrew University, Hadassah Medical School in 1952. She moved to Houston with her husband, Dr. Joseph L. Melnick, in 1958. In 1976 she began her residency in psychiatry at Baylor College of Medicine. At Baylor College of Medicine she held professorships in both the Department of Virology and Epidemiology as well as the Department of Psychiatry. She worked closely with her husband on his research on poliomyelitis as well as conducting her own research in myoplasma and it's relationship with cancer development in certain animals. Dr. Benyesh-Melnick died July 19, 2020, in Houston.