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This collection consists of the records of the Friends of the Texas Medical Center Library, beginning with the organization's incorporation in 1960. There are materials relating to the Friends Board and administration, fundraising and gifts, events, and publications.

Materials include meeting minutes, financial records, correspondence, invitations, photographs, newsletters, and other administrative records relating to the organization and its operations.

The collection also features an Oral History Project, launched in 2023.

Houston Academy of Medicine records consists of about 18 boxes and contains reports, financial and legal documents, correspondence, and printed material that document the history of the Houston Academy of Medicine.