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The Harris County Hospital District collection primarily consists of patient records, emergency room logbooks, tuberculosis logbooks, hospital operations logbooks, and baby logbooks. The collection also includes copies of The Beat and Progress newsletters, annual reports, records, telephone directories, employee handbooks, budget information, an eligibility procedure manual, and other printed material.

The Texas Medical Center (TMC) Photograph Collection contains photographic materials that document the growth and development of the TMC from the 1930s to 1980s. The collection consists of 2525 items and includes photographic prints, aerial photographs, negatives, transparencies and printed materials. The materials depict the institutions of the TMC, their staff, facilities, services, and patient care. Images show buildings and their construction as well as some photographic copies of architectural renderings. Aerial photographs from the 1940s to 1980s show the TMC grow from marshland to an urban center. The collection provides images of the leaders and historical figures that shaped the TMC from concept to reality. The collection totals 7 boxes, equaling 3.5 cubic feet. The materials are in good condition.