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Department of Physiology, Harvard Medical School. Department of Physiology, University of Pittsburgh School of Medicine Collaborators and fellows: R.O. Greep, R.C. Wolf, J.L. Kostyo, P.F. Brande, H.M. Goodman, J. Hotchkiss, M.J. Franklin, W.D. Peckham, G.R. Fritz, B. Katorski Zain, J.B. Josimovich, R.J. Schimmel, P. Lebovitz, H. Friesen, H. W. Sokol, R.K. Black Monkey experiments, nitrogen determination by microKjeldahl method (1953-54) Growth hormone infusion tests (1954-56) Acute GH "A" Monkey Book I (1953-54) Monkey Book II (1954...) Daily log books 1 (1955-56), 2 (1956-58), 3 (1958-60) Prolactin

Nitrogen data, book I (1955-56); book II (1956-57); book III (1957); book IV (1957-58). Growth hormone assay, (1955...) Bovine and monkey growth hormone preparations 35Sulfate incorporation into costal cartilage of rats and monkeys (the effects of plasma from growth hormone-treated animals) (1958) Monkey survey - summary of GH treatments to all animals (1954....) Experiment 25: (1956) nature unknown.

Protein synthesis, Book I (1959-60), effect of primate and bovine growth hormone on glycine- or phenylalanine- 2-14C incorporation into the hemidiaphragms of hypophysectomized rats, Book II (1960); Book III (1960), Book IV (1960), Book V (1961) Amino acid incorporation and transport.

Department of Physiology, University of Pittsburgh School of Medicine Collaborators and fellows: V. Meyer, M. Sakuma, M.H. Taylor, R. Guillemin, A.V. Schally, W.D. Peckham, Radioimmunoassay of growth hormone, Books 1-6 (1963-64). HGH = human growth hormone, sGH = simian growth hormone.

Radioimmunoassay of growth hormone, Books 7-9 (1964-1965). Regulation of GH in feeding, fasting, insulin hypoglycemia, pitressin, pig hypothalamic extracts, cortical extracts, epinephrine, estrogens

Department of Physiology, University of Pittsburgh School of Medicine Collaborators and fellows: J.D. Neill, S.E. Monroe, L.E. Atkinson, A. Bhattacharya, J.K. Datta, T. Yamaji, W.D. Peckham Ovine LH, simian LH, human LH, simian FSH, Prolactin. Folder: Ovine LH Radioimmunoassays 1-13, 1967. Simian LH Radioimmunoassays: Book I, assays 1-40 (1966-1968); II, assays 41-44 (1968). III (missing, no book found). IV, assays 52-64 (1969...). LH Radioimmunoassay Book I, September through December, 1965, Assays 1-11.

Department of Physiology, University of Pittsburgh School of Medicine Collaborators and fellows: A.H. Surve, J.D. Neill,. J. Hotchkiss, E.D.B. Johansson, F.J. Karsch, R.L. Goodman Progesterone (1966-70). Book I: 1966 Protein-binding method of Murphy. 6/28/66 and on. . No numbered books follow. Some seem to be missing. Assays 1-65 1969: Surve I..CBG; 1969, Surve II;1969-1970; Progestins;. 1970 Surve IV

XVII: (#117). 197112-1973. Stress and the LH surge, LRF in the follicular phase, LH in ovulation timing studies, scopolamine and the EB-induced surge, L-DOPA and gonadotropin secretion, prolongation of the luteal phase progesterone level and gonadotropin secretion, effect of chronic nembutal and the EB -induced surge. In ovx animals: scopolamine, 5-hydroxytryptophan, 17?-hydroxyprogesterone, dexamethasone, phenoxybenzamine, prolonged pentobarbital or morphine, pituitary LH and FSH content. In males: diurnal variation in testosterone, effect of testosterone propionate on LH secretion in the castrate. XVIII: (#118). 1973. EB studies in Population Council animals. Prolonged pentobarbital and LH surge, refractory period, effects of thyroidectomy on TSH secretion, thyroid and adrenal weights, p-chlorophenylalanine, reserpine, L-DOPA effects, induction of the LH surge with chlorpromazine. In ovx animals: scopolamine, induction of the LH surge in ovx-adrex animals, effects of the withdrawal of cortone acetate in the ovx-adrex animal. In males: diurnal variations in testosterone in T-implanted castrates, LRF in intact males. Regulation of Gonadotropin Secretion XIX: (#119) 1973-1974. Supersuppression of TSH with thyroxin, blockade of surge with reserpine, chronic scopolamine, does rabbit-15 immunoassayable material (LH-like material) rise when rhesus LH fails to? (in immature, lactating, ovariectomized females, or immature males). Thyroid collection. Split stimulus: estradiol and progesterone. Does elevated estradiol cause premature parturition? CB154 in the luteal phase, luteotrophic effect of prolactin (protocol). Acute scopolamine or morphine, LH after acute estradiol benzoate, LRF pulses and haloperidol, serum estrone levels after estrone implant. In males: Testosterone dynamics in the castrate, gonadotropins in castrate immature males, estradiol and testosterone variations in intact males, effect of testosterone on tonic LH secretion.

Looseleaf folder: Follicular development, with Polaroid slides, 1969 Looseleaf folder: Hypophysectomy, hysterectomy, and early progesterone data, 1966- 1967. Looseleaf folder: HCG treatment, 1968-1969. Looseleaf folder: Maintenance of adrenalectomized monkeys with implants of 9?-fluorohydrocortisone acetate. looseleaf folders:

B. Radiofrequency lesions in the MBH and GnRH replacement (continued):Box 3 of 4 Book 19 (#319), 1979-1981. See book 317. Book 20 (#320), 1980-1981. Methods, GnRH infusion lab, tests of infusion systems, weekly checks of GnRH stocks, pulse volumes delivered, Book 21 (#321), 1979-1981. See book 319. Monkey 689, monkey with Turner's syndrome Book 22 (#322), 1979-1980. See book 321. Book 23 (#323), 1980-1982. Maintenance of the corpus luteum by the hyperprolactinemia seen with MBH lesions. Protocol, 1980. Book 24 (#324), 1979-1981. See book 323. Book 25 (#325), 1980-1981. See book 324. Book 26 (#326), 1980-1981. See book 325. Book 27 (#327), 1980-181. See book 326. Looseleaf folder: Summary of data on pre- and port-MBH lesion responses to estradiol benzoate, on the progesterone blockade, and on the "GnRH stop" experiments. These data are keyed to the "300 series" books.

B. Radiofrequency lesions in the MBH and GnRH replacement (continued): Box 4 of 4 Timers and pumps books (3): 1. 2/9/1978-2/13/1979. 2. 2/14/1979-8/1980. 3. 9/11/80-6/21/1982. Water intake book, 1/4/1975 on. Associated with RF lesions and Halasz cuts. Looseleaf Folder AM/FM data compiled

C. Electrical recording in the mediobasal hypothalamus (continued): Box 7 of 80 Animal 1343 (Books 9-12 of 27, 1990-1992). Hypothalamic monitoring via telemetry throughout pregnancy and postpartum, (baby delivered July 13, 1992)

C. Electrical recording in the mediobasal hypothalamus (continued): Box 11 of 80 Animal 1343 (Books 25-27 of 27, 1994-1997). Telemetry during lactation, foster mother studies

C. Electrical recording in the mediobasal hypothalamus (continued): Box 18 of 80 Animal 1400 ( 3 books, 1986-1996). Ovariectomized 1991. Fixed electrodes #1 (1987-1988); #2 (1989); #3 (1989-1996). Volley duration after ovariectomy study, insulin hypoglycemia, effect of light and dark on MUA frequency, telemetry, 17?-estradiol study, estradiol capsules, euthanasia 1996. Animal 1414 (Books 1-2 of 7, 1985-1997). Ovariectomy 1990.Fixed electrodes #1 (1986-1987); #2 (1988-1997). Naltrexone, naloxone, telemetry during the menstrual cycle ± estradiol benzoate treatment, follicular phase and surge time courses, preovulatory progesterone treatment, insulin hypoglycemia, ovariectomy, volley duration changes after ovariectomy.

C. Electrical recording in the mediobasal hypothalamus (continued): Box 19 of 80 Animal 1414 (Books 3-7 of 7). See box 14 for details

C. Electrical recording in the mediobasal hypothalamus (continued): Box 26 of 80 Animal 1127 ( 1 book, 1990-1992). Ovariectomized 1992. Fixed electrodes (1991-1992). MUA changes after ovariectomy, lights on/lights off, foster mother ± telemetry. Died 1992. Animal 1171 (2 books combined into 1, 1985-1989). Ovariectomized 1988. Fixed electrodes #1 (1986); #2 (1987); #3 (1988); #4 (1989). Time course after bromocriptine. Sacrificed 1989. Animal 1191 (1 book, 1982-1983). Ovariectomized 1981. Fixed electrodes #1 (1982) . MUA with pentothal anesthesia and while awake. Electrodes lesioned and sacrificed , 1983. Animal 1206 (3 books combined into 2, 1984-1993). Ovariectomized 1988. Fixed electrodes #1 (1986); #2 (1987); #3 + ICV(1988-1990); #4 (1990-1991); #5 (1992); LH and FSH., pentothal + naloxone, prolactin, CRF ± naloxone, GnRH, estradiol infusion, morphine ± naloxone, AP-5, estradiol implant ± naloxone, given to Fellerman 1993.

C. Electrical recording in the mediobasal hypothalamus (continued): Box 28 of 80 Animal 1269 (books 1-5 of 7, 1984-1994). Ovariectomized 1988. Fixed electrodes #1(1986-1987); #2 (1987-end). Telemetry, CRF, morphine, NMDA, progesterone, insulin hypoglycemia, lights on/lights off, foster mother with telemetry, foster mother ± estradiol implant, BrainWaves study, Estradiol benzoate induced surge in telemetry, euthanasia 1994.

C. Electrical recording in the mediobasal hypothalamus (continued): Box 34 of 80 Animal 1391 (1 book, 1982-1985). Ovariectomized 1982. Fixed electrodes #1 (1983). Metoclopramide, yohimbine, TRH(hyperprolactinemia), GnRH agonist, morphine ± naloxone, sacrificed and perfused and brain sent to Dr. Silverman. Animal 1393 (1 book, 1983-1985). Ovariectomized 1983.Fixed electrodes #1(1982). Sacrificed 1985 and perfused and brain sent to Dr. Silverman. Animal 1397 (2 books, 1984-1990). Ovariectomized 1987. Fixed electrodes #1 (1987-1988); #2 (1988), #3 (1988-1990). Time course cage and chair, CRF± naloxone, estradiol implant, morphine ± naloxone, NMDA, died 1990. Animal 1469 (2 books, 1987-1993). Ovariectomized 1991. Fixed electrodes #1 (1989-1990); #2 (1990); #3 (1990-1992). Volley duration after ovariectomy.

C. Electrical recording in the mediobasal hypothalamus (continued): Box 39 of 80 Animal 1530 (3 books, 1987-1995). Fixed electrodes #1 (1987-1990); #2 (1990-1991); #3 (1991-1992), #4 (1992); #5 (1992-1993); #6 (1993-). Progesterone, telemetry trials, euthanasia 1995. Animal 1535 (1 book, 1992-1994). Ovariectomized 1993. Fixed electrodes #1 (1992); #2 (1993); Moveable electrodes #3 + ICV (1993). Insulin hypoglycemia ± antiCRF, L-NMMA ± antiAVP, Na nitroprusside. Died 1994. Animal 1546 (2 books, 1987-1991). Ovariectomized 1989. Fixed electrodes #1 (1988-1991). Volleys after ovariectomy, progesterone, insulin hypoglycemia ± naloxone ± estradiol capsule. GABA. ICV 1991. Died 1991.

C. Electrical recording in the mediobasal hypothalamus (continued): Box 41 of 80 Animal 1590 (2 books, 1987-1991). Ovariectomized 1988. Fixed electrodes #1 (1987-1989); #2 (1989-1991). Habituation and naltrexone, insulin hypoglycemia, morphine. Animal 1596, (Books 1-4 of 6, 1987-1993). Ovariectomized 1987. Fixed electrodes #1 (1987-1988); #2+ ICV (1988-1993). CRF ± metyrapone, CRF ± naloxone, GnRH, morphine ± naloxone, estradiol ± naloxone, NMDA ± morphine, NMDA ± phenoxybenzamine, telemetry, light/dark ± noise, aCSF, AP5, norvaline, naloxone ± alcohol, progesterone, long acting GnRH, transmitter tests, insulin hypoglycemia ± naloxone ± estradiol, BrainWaves, telemetry, CB154 and pulse generator, EB-induced LH surge, died 1993.

C. Electrical recording in the mediobasal hypothalamus (continued): Box 44 of 80 Animal 1664 (2 books, 1987-1994). Ovariectomized 1990. Fixed electrodes #1 (1987-1988); #2 (1989-1991); #3 (1991....). LH and GH, volleys after ovariectomy, lesioned Animal 1680 (books 1-3 of 6, 1986-1993). Ovariectomized 1987. Fixed electrodes #1 (1986....). CRF ± morphine, CRF ± metyrapone, CRF ± naloxone, naloxone ± morphine, naloxone ± estradiol, NMDA ± morphine, NMDA ± phenoxybenzamine, progesterone, BrainWaves, insulin hypoglycemia ± rCRF 12-40 antagonist, light/dark, GABA, alpha-helical CRF, melatonin, telemetry, MK801, CPP icv, TRH, foster mother in telemetry, CB154, transferred 1993.

C. Electrical recording in the mediobasal hypothalamus (continued): Box 46 of 80 Animal 1693 ( Books 2-6 of 6). See box 41 for details

C. Electrical recording in the mediobasal hypothalamus (continued): Box 55 of 80 Animal 1803 (4 books, 1991-1996). Fixed electrodes #1 91991); #2 (1991-1992); #3(1992); #4 (1992-1993), #5 (1993); moveable electrodes #6 (1993...). Telemetry and lactation, euthanasia 1996. Animal 1804 (book 1 of 6, 1989-1997). Fixed electrodes #1 (1989-1990), #2 (1990-1993); moveable electrodes #3 (1993-1997). Telemetry cycles, follicular, and luteal and LH surge time courses, progesterone, insulin hypoglycemia ± naloxone, melatonin, light/dark, CB154 and pulse generator, antiestrogen ICI 182780, telemetry with foster mother and lactation trials. ICV 1995. She does not accept foster babies.

C. Electrical recording in the mediobasal hypothalamus (continued): Box 60 of 80 Animal 1868 (1 book, 1989-1990). Fixed electrodes #1 (1989), #2 (1990). EB treatment, insulin hypoglycemia. Animal 1871 ( books 1-4 of 6, 1990-1996). Ovariectomized 1992. Icv 1993. Fixed electrodes #1 (1990-1991); #2 (1992); #3 (1992...). Insulin hypoglycemia ± naloxone, telemetry, insemination, CB154, AVP ± antiAVP, Prl and LH, insulin hypoglycemia ± antiAVP, L-NMMA ± antiAVP, D-NMMA, insulin hypoglycemia ± CRF analog, antiestrogen (ICI), icv volume tests, hPRL, antide, aCSF, NPY-Y analog (PXY-2),, euthanasia 1996.

C. Electrical recording in the mediobasal hypothalamus (continued): Box 67 of 80 367, 1 book 1995-97, moveable electrodes #1 (9-25-95). No MUA. Euthanasia. 4-7-97 827C, 1 book 1995-97, moveable electrodes #1 (10-24-95). No MUA. Euthanasia 1-30-97 829C, 1 book 1995-97, moveable electrodes #1(10-3-95). No MUA. Euthanasia 2-4-97 1509, 2 books 1987-92, fixed electrodes #1 (10-29-87 to 11-29-89), #2 ( 1-11-90 to 7-29-91), #3 (1-14-92 to 4-30-92). No MUA 1446, 2 books, 1985-1995, ovariectomy 1/10/91, Fixed electrodes #1 (12-23-86. ), #2 (4-10-89 to 2-13-90), #3 (2-22-90 to 6-20-91), #4 moveable electrodes (10-28-93 to 6-22-95 euthanasia). No MUA

C. Electrical recording in the mediobasal hypothalamus (continued): Box 70 of 80 1178, 1983-1985, ovariectomized 1-3-83. Fixed electrodes #1 (7-26-83 to 2-9-84). #2 (2-22-84 to 10-25-84). Stress+naloxone, phenoxybenzamine time course, sold 1985. 2 books 1189, 1982-1984. Ovariectomized 11-29-83. Fixed electrodes 5-8-84...loose, sacrificed 6- 6-84. M-2, MALE, collection of serum for RIA (same book as 1189). 1210, 1987-1991. Ovariectomized 7-28-88. Fixed electrodes #1 (3-1-88 to 1-17-89). #2, (3-9-89 to 12-21-90). #3, (6-27-91 ...). Died 7-24-91 1217, 1989-1990. Fixed electrodes + icv (11-16-89 to 9-19-90) 1223, 1982-1984. Ovariectomized 12-3-81. Recording well implantation (5-14-82 (Pittsburgh) -5-20-83). 1247, 1983-1984. Ovariectomized 10-4-83. Fixed electrodes (1-31-84). 1251, 1982-1987. Ovariectomized 2-11-82. Recording well implantation (11-15-82 to 7-19-83). Fixed electrodes #1 (8-11-83 TO 10-25-84), #2, (9-3-85...)

C. Electrical recording in the mediobasal hypothalamus (continued): Box 74 of 80 1473, 1986. Electrodes #1 (10-2-86 to 12-15-87); #2, (aborted). Quercitin 1527, 1987--1989. Ovariectomized 3-29-88. Electrodes #1 (10-22-87 to 8-17-88), #2 10- 26-88 to 9-19-89), #3 5-18-89 to ---) LH, GH 1532, 1992-1996. Electrodes #1 (12-10-92 to 6-3-93), #2, Moveables 8-19-93 to 3-15- 94), #3, moveables, 9-27-94 to 5-4-95). Lactation foster attempt, gave to Crawford 2/15/96. 1537, 1987-1989. Electrodes #1 (6-8-89..) Died 9/12/89. 1593, 1984-1985. Ovariectomized 12-3-84. Electrodes #1 (7-10-85..) Died 1599, 1989-1990. Ovariectomized 1983. Electrodes #1 8-2-90 to 10-8-90). 1600, 1988-1989, Ovariectomized 19183. Sick a lot, sacrificed 1-25-89.

E. Postpartum lactational amenorrhea continued): Box 4 of 4 Monitoring Suckling Behavior, Books 3-5 of 5. Foster mother bleed sheets, weights of infants (1975-77), ovariectomized foster mother data

F. Methods, studies, protocols, technical developments (continued): Box 7 of 14 Radioimmunoassay and bioassay development Protein Hormone Radioimmunoassay Books, Houston Reagents and iodinations, etc., 1982-1989, LH, FSH, GH, etc., Gonadotropin assays + EGF RIA, 1989-1996 125I RIA book Protein Hormone RIA's Quality control, 1981-1989. LH RIA book, 1987 -- GnRH RIA, 1991-1997 (2 books)

F. Methods, studies, protocols, technical developments (continued): Box 11 of 14 Radioimmunoassay and bioassay development "H series" books, continued. Book 4, 1985 + B0010-16; Book 5, 1985-1986, B0017-24; Book 6, 1986, B0025-29

F. Methods, studies, protocols, technical developments (continued): Box 13 of 14 Radioimmunoassay and bioassay development "H series" books, continued. Book 9, 1987-1988, B0083. Book 10, 988-1989; Book 11, 1989-1990; Book 12, 1990.

G: Brain Waves Analyses (continued) Box 2 of 2 Books 11-13 of 13. Book 11: 1991, Animal 1680. Book 12, index of sorts Book 13: 1990, Animal 1546 space for more books more books to come